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  • Single-Molecule FRET

    The lab of Prof. Keith Weninger develops single-molecule fluorescence methods to study biomolecular systems, with a particular focus on FRET to study proteins involved in DNA mismatch repair. Prof. Weninger further explained his research, “I do single-molecule FRET experiments on tethered DNA molecules with surface-immobilized TIRF microscopy.”

  • Light Sheet and Single Molecule Tracking

    The Cambridge Advanced Imaging Centre (CAIC) at the University of Cambridge develops modern imaging techniques to answer some of the most pressing and challenging biological questions. Keeping in mind the needs and demands of biologists, one of the current developments is a localization based 3D super-resolution microscope

  • Single Molecule TIRF

    The Klenerman group at the University of Cambridge investigates intracellular signalling in T-cells, a vital component of the human adaptive immune response. They are particularly interested in the kinetic-segregation model of T-cell signalling which proposes that signalling is only possible when CD45 molecules on the T-cell surface are sterically excluded from the T-cell receptor site.

  • What Is Neuroscience?

    Neuroscience is the study of the nervous system, and is one of the most interdisciplinary and rapidly‑advancing scientific fields, with branches in computer science, medicine, biology, and psychology. The areas of study within neuroscience are also broad, from more abstract concepts such as thought, emotion, and memory to the behavioral characteristics of all animals such as sleep, movement, socialization and also the breakdown of these systems during disease.

  • How Is An Image Made?

    Cameras are incredible tools that allow us to capture and make sense of the visible world around us. Most mobile phones made today come with a camera, meaning that more people than ever are becoming familiar with camera software and taking images.

  • Camera Test Protocol

    The detector is one of the most important components of any microscope system. Accurate detector readings are vital for collecting reliable biological data to process for publication.To ensure your camera is performing as well as it should be, Photometrics designed a range of tests that can be performed on any microscope.

  • Introduction To Light Sheet Microscopy

    During the last two decades, microscopy has been constantly trying to exploit new boundaries. By aiming for smaller details, cameras and other detectors needed to become more sensitive and less noisy due to less available photons per resolvable detail

  • iSPIM and diSPIM

    Light sheet microscopy overcomes the challenges of imaging physiological processes. Light exposure can result in phototoxic effects and photodamage on biological samples, which can disrupt cellular functions.

  • Imaging In Color

    Life is full of color, and capturing an image that replicates human perception of color is an important, and sometimes challenging, aspect of both everyday life and scientific research. Although many cameras, such as phone cameras, video cameras, and commercial digital cameras, produce color images, a large portion of scientific research is carried out using monochrome cameras.

  • Lattice Light Sheet

    Light sheet is one of the fastest growing fields in microscopy due to the low cost, flexibility and fast 3D imaging of large samples. In other microscopy techniques, the illumination and imaging systems use the same light path and on the same axis.

  • Köhler Illumination

    In microscopy, we aim to produce a sharply-defined, magnified image of our sample in our detector or our eyes. The sample requires illumination for us to see it – but how do we avoid simply seeing a sharply-defined, magnified image of the LED, bulb filament or arc lamp of our light source? Instead, we require even, uniform illumination of our sample, free from structures and patterns, no matter what light source we use.

  • Programmable Scan Mode

    Applications such as light-sheet microscopy and spinning disk confocal microscopy often utilize rolling shutter readout of CMOS sensors to enhance image quality. Programmable Scan Mode (PSM) allows additional control over the rolling shutter and readout, such as adding delays to groups of rows and changing the readout direction. PSM can be found on our Prime and Kinetix families of CMOS cameras.