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  • Live Yeast Vacuole Imaging

    Prof. Mayer and group work to study the cell membrane, especially the processes of membrane fusion and fission, exploring the molecular machinery that drives these reactions. Of particular interest are endosomes, lysosomes and other components of the endolysosomal system, which routinely fuse amongst each other to transfer cargo proteins or with the cell membrane to initiate repair and to release their contents out of the cell.

  • Functional Calcium Retinal Imaging

    Prof. Jösch is the head principal investigator of a functional imaging neuroscience group who are currently studying retinal processing in mice with a novel imaging method. The group wants to understand how the brain receives information about the surrounding world and how the information is processed and computed by the brain, using the retina as a window through which to study the brain.

  • OPM Snouty Light-Sheet

    Dr. Edward Ward and Mr. Jacob Lamb are both researchers in the Laser Analytics Group, led by Prof. Clemens Kaminski. This group aims to develop imaging techniques to apply to biological systems, requiring the latest in optical and camera technologies.

  • Patch Clamp Electrophysiology

    The EPFL houses the Laboratory of Neural Microcircuitry (LNMC), which is dedicated to researching and unraveling the structure and function of neural microcircuits, particularly in the neocortex. This group is headed by Prof. Henry Markram and includes research scientist Dr. Rodrigo de Campos Perin, who is working with a combination of fluorescence microscopy and patch clamping for intracellular electrophysiological recordings.

  • Single Molecule Biophysics

    Dr. Christoph Baumann, Lecturer at the University of York, Department of Biology and his group work with advanced imaging techniques to push forward our understanding of spatio-temporal dynamics in the bacterial cell envelope. Using a Photometrics camera, the group was the first to observe that, contrary to expectations, proteins in the outer cell membrane don’t diffuse significantly when tracked, and that new proteins are inserted predominantly at mid-cell during growth.

  • Whole Heart Light Sheet

    Dr. Leonardo Sacconi is a senior researcher at the National Institute of optics and group leader of the Cardiac Imaging Group, which aims to develop novel imaging modalities for research into cardiovascular physiology and pathology. Using techniques such as calcium imaging, multiphoton excitation, and light sheet, Dr. Sacconi is able to investigate both the structure and function of cardiac tissue.

  • Novel Structured Illumination Microscopy

    Prof. Bernd Rieger works with applied physics at TU Delft, and tells us about his research, “We are an applied physics and engineering group researching computational microscopy and building microscope systems, improving spatial resolution and temporal resolution of imaging systems. We start with empty optical tables and then build our systems.”

  • Fluorescence and Electrophysiology

    Prof. Naoki Yamawaki is a neuroscientist at Aarhus University, who told us about his research, “We are interested in understanding how stress affects the neuronal connections and communication in the brain, I am responsible for running the lab, doing experiments, mentoring, teaching students, and more.

  • NIR/VIS Brain Imaging

    The lab of Professor Marc Spehr is working on the olfactory system of mammals and the underlying mechanisms of pheromone detection. Pheromone detection is key for social communication in the animal world

  • Advice On Choosing A Camera For Calcium Imaging

    The key specifications to look for in a camera for calcium imaging will depend broadly on the type of calcium imaging being performed. From the perspective of the camera, the simplest way to divide calcium imaging would be into two application areas; neuronal calcium imaging and cardiac calcium imaging.

  • Digital Interfaces

    Digital interfaces allow scientific cameras (and other imaging or microscopy hardware) to communicate with computers, typically for data transfer so that images acquired during experimentation can be stored for analysis and processing.

  • Intrinsic Signal Optical Imaging

    The brain is one of the most complex objects in the known universe, both in terms of structure and function. This makes imaging the brain an incredibly challenging task, with researchers looking at the movement of signalling ions (see app note on Calcium Imaging), structure of cells and the electrical activity of neurons (see app note on Electrophysiology).