Search

  • Light Sheet Optical Thermometry

    Dr. Brian Patton and Ph.D. candidate Petros Hadjichristodoulou are involved in microscopy development and incorporating technologies into imaging. One such technology is the use of nanodiamonds (NDs), these contain natural defects known as nitrogen-vacancy centers that can be modulated by illuminating the NDs, which will emit fluorescence.

  • High-Speed Single Molecule Light Sheet

    The lab of Dr. Aleks Ponjavic develops fluorescence microscopy techniques in order to study live-cell samples, including particularly mechanically delicate and photosensitive samples such as T cells. These live samples undergo complex processes and require high-speed imaging, sensitivity, and nanoscale resolution in order to determine the behavior of individual proteins within the cells.

  • Nematostella OPM Light Sheet

    Dr. Rory Power is a staff scientist and engineer at the advanced imaging center of the EMBL headquarters in Heidelberg. Involved in a variety of projects, Dr. Power also oversees Ph.D. students involved in building custom light sheet imaging systems.

  • Single Molecule Detection

    The Shen lab at Kent State University are using single-molecule imaging approaches to evaluate catalytic reactivity of various carbon nanoparticle formulations. Electrochemical reactions are critical to energy conversion and storage, but mechanisms to understand key parameters at the molecular level have been lacking.

  • Super-Resolution Single Molecule Localization

    Single-molecule localization microscopy (SMLM) techniques, such as photoactivation localization microscopy (PALM), achieve some of the highest spatial resolutions among all the super-resolution imaging methods. However, image reconstruction in PALM requires a large number of raw images, which leads to low temporal resolution

  • SRRF and Super-Resolution Microscopy

    The Henriques group use various super resolution microscopy techniques to investigate cell signalling and host-pathogen interactions as well as creating and developing technology for cell biology research.A big challenge in super-resolution microscopy is the requirement for intense illumination but this is usually phototoxic and incompatible with live-cell imaging.

  • STORM Super-Resolution

    The laboratory of Dr. Rothenberg at the New York University School of Medicine focuses on new optical methods to study biological molecules and processes at real time and nanometer scale. The Rothenberg research team studies the mechanisms of enzymes and proteins that participate in repair of DNA damage leading to cancer, and develops new imaging methods that will enable them to visualize the behavior of individual biological molecules.

  • Multifocus and Snouty Light Sheet Microscopy

    Dr. Florian Ströhl leads a group of physicists to develop advanced microscopy systems, including a new light-sheet imaging system. This custom light-sheet system involves a single-objective oblique plane microscopy (OPM) approach using the Snouty lens, as well as additional capabilities for 3D imaging.

  • Super Resolution Bacterial Imaging

    Dr. Holden’s research lies between biophysics and microbiology, using super-resolution microscopy to study basic principles of bacterial spatial organization. In particular, the Holden Lab focuses on how the Gram-positive model bacterium Bacillus subtilis divides, and how the bacterial cytoskeleton guides the construction of a mid-cell cross-wall or septum.

  • Pattern Noise: DSNU and PRNU

    The sensitivity of a scientific camera is vital, with insufficient sensitivity it may not even be possible to acquire clear images of your sample. At Teledyne Photometrics sensitivity is paramount and is our approach to highly sensitive cameras is twofold: maximize signal collection, and minimize noise levels.

  • Super-Resolution Microscopy at The Laboratory of Experimental Biophysics EPFL

    Dr. Kyle Douglass, a research scientist at the EPFL, has spent the past several years developing high-throughput and automation methods for super-resolution fluorescence microscopy. The Laboratory of Experimental Biophysics, which is led by Prof. Suliana Manley, uses these techniques to study the structural biology of multi-protein complexes such as chromatin foci, the bacterial division machinery, and the centrosome.

  • Triggering

    As discussed in our previous article on rolling vs global shutters, our camera range uses electronic shutters, meaning the sensor is continuously exposed with no mechanical shutter or aperture to block light to the sensor. These cameras continuously read out the sensor when in operation, and can produce an image upon request by software, which is the image you see on your computer.