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Super-Resolution Expansion Light Sheet
The lab of Prof. Ulrich Kubitscheck works to analyze living as well as cleared biological cell systems, developing novel quantitative light microscopy techniques. A combination of tissue clearing with light-sheet fluorescence microscopy (LSFM) is especially well suited to the fast analysis of complex arrangements of large cleared cell clusters and thus allows fast light microscopic access into the complex 3D architecture of neuronal tissue.
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Multi-Patch Clamp Electrophysiology
Dr. Maurizio Pezzoli works in the Neural Microcircuitry Laboratory, performing whole-cell patch clamping in acute slices in order to analyze local microcircuitry. The main approach is through multiple patch-clamp, as Dr. Pezzoli says “the lab has the first 12 patch system so we can put 12 pipettes in one slice and see how close neurons talk to each other”.
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Sub-cellular Oblique Plane Microscopy
Dr. James Manton develops new microscopy techniques in the MRC Laboratory of Molecular Biology, Cambridge. A recent development project involves an oblique plane microscope (OPM) with a Mr. Snouty solid-immersion objective, which combines the speed and efficient illumination of light-sheet with the ease of use of a traditional inverted microscope.
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Single Molecule DNA Imaging
The NanoBioPhotonix Lab of Tel-Aviv University is led by Prof. Ebenstein and focuses on single-molecule genomics research and development of novel imaging techniques. Jonathan Jeffet is a PhD student and physicist from this highly multidisciplinary lab and works with their imaging systems performing optical genome mapping.
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Live Cell Spinning Disk Confocal
The Center for Organismal Studies (COS) Heidelberg has set the goal of researching organismal biology beyond the boundaries of the biological organizational stages. Research and teaching at the COS are devoted to the biology of organisms from the molecular basis to cell biology, developmental biology and physiology to evolution and biodiversity as well as system biology and biotechnology in plant and animal systems.
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Plant Bioluminescence
Dr. Matt Jones leads a group of circadian biologists working at the University of Glasgow, who research internal circadian rhythms in plants and how they respond to light at different times of day, with an aim to manipulate these responses and improve plant growth and crop yields.
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Optical Fiber Photometry
Dr. Priya Rajesethupathy and colleagues in the Rockefeller University Laboratory of Neural Dynamics and Cognition are interested in the process of memory. Integrating approaches ranging from genomics, transcriptomics, optogenetics and imaging, they aspire to address memory formation and recall at scales ranging from the synapse through to collections of hundreds to thousands of neurons and finally animal behavior.
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Gene Expression via Bioluminescent Reporters
The research performed by the Locke Group at the University of Cambridge focuses on developing a quantitative understanding of gene circuit dynamics. One of the gene circuits of particular interest is the circadian clock, the biological timekeeper.
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High-Throughput Spinning Disk Confocal
Dr. Tom Lummen is a microscopy engineer at ETH Zürich University, and spoke to us about the imaging facility he works with, “I’m part of the microscopy team that operates the imaging core facility, we provide 20 high-end automated microscopes for the imaging needs of the users of our department
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Neuronal Single-Molecule TIRF
Marco Schnieder is a PhD student in the group of Prof. Klingauf, whose research focuses on neuroscience, mainly the physiology of synaptic transmission, and the mechanisms of synaptic vesicle recycling, in particular endocytosis.
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Calcium and Voltage Imaging
Dr. Naoki Kogo is a visiting researcher in the lab of Prof. Nael Kasri, participating in projects to study the neural properties of network dysfunction in neurodevelopmental disorders.
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Dynamic Microfluidic Imaging
The Knowles Lab at the University of Cambridge is an interdisciplinary group that develops new approaches to probe the behavior of biological molecules, especially protein self-assembly, a process that can result in several neurodegenerative diseases when misfolding occurs.