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Microfluidic Live Yeast Imaging
The Rine lab at the University of California, Berkeley is working towards understanding mechanisms underlying establishment, maintenance, and epigenetic inheritance of gene silencing in yeast. The lab has developed a genetic strategy to capture transient losses of gene silencing of heterochromatin in S. cerevisiae, and translating these dynamic processes as a permanent modification of fluorescence expression.
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Novel Hyperspectral Imaging
The interdisciplinary laboratory led by Prof. Silas Leavesley and Dr. Thomas Rich is working to develop novel hyperspectral imaging systems for microscopy and endoscopy. Using rapidly controllable light sources with precise spectral selection they aspire to be able to increase the number of individual sensors and probes detected concurrently.
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High Content Multiplex Fluorescence
Dr Sonia Leonardelli of the Hölzel Lab performs fluorescent imaging of a range of different tumour tissue samples, one of the main projects being to study cell-cell interactions in adenocarcinoma. The fluorescence imaging in this lab using the CODEX® system from Akoya Biosciences® with a Zeiss microscope in order to take multiple fluorescence images with multiple different fluorophores, which can then be collated and output with all the fluorophores in the same image, up to 60 different types.
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Light Sheet Microscopy at Morgridge Institute for Research
Dr. Jan Huisken, Director of Medical Engineering at the Morgridge Institute for Research has been instrumental in the invention and development of Light Sheet Microscopy. One of his current research interests is in the development of novel methods to image cleared tissues.
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Live Cell Imaging at Heidelberg University Medical School
The Frischknecht lab aims to understand transmission of the malaria parasite between host and mosquito. The lab focuses on the two motile stages of the life cycle – the ookinete and the sporozoite using the rodent model parasite Plasmodium berghei.
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Imaging With A Quantum Light Source
Dr. Gräfe and Ms Gilaberte-Basset’s research and development centres around quantum imaging light sources. The group is currently building a new light source that will make use of quantum imaging to permit excitation of samples in the UV range, whilst detecting in the visible range, through the manipulation of correlated photons.
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Single-Molecule Biophysics
The Freedman Lab studies single molecule biophysics using a variety of electrical and optical signal measurements. Most notably, the lab studies complex biological systems where molecular populations are heterogeneous and difficult to study using ensemble averaging.
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Mizar TILT Light Sheet
Conventional light sheet fluorescence microscopy (LSFM) is performed with two objectives oriented orthogonally to each other so that one objective introduces the light sheet and the other detects the fluorescence signal.
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Live Yeast Vacuole Imaging
Prof. Mayer and group work to study the cell membrane, especially the processes of membrane fusion and fission, exploring the molecular machinery that drives these reactions. Of particular interest are endosomes, lysosomes and other components of the endolysosomal system, which routinely fuse amongst each other to transfer cargo proteins or with the cell membrane to initiate repair and to release their contents out of the cell.
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Functional Calcium Retinal Imaging
Prof. Jösch is the head principal investigator of a functional imaging neuroscience group who are currently studying retinal processing in mice with a novel imaging method. The group wants to understand how the brain receives information about the surrounding world and how the information is processed and computed by the brain, using the retina as a window through which to study the brain.
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OPM Snouty Light-Sheet
Dr. Edward Ward and Mr. Jacob Lamb are both researchers in the Laser Analytics Group, led by Prof. Clemens Kaminski. This group aims to develop imaging techniques to apply to biological systems, requiring the latest in optical and camera technologies.
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Patch Clamp Electrophysiology
The EPFL houses the Laboratory of Neural Microcircuitry (LNMC), which is dedicated to researching and unraveling the structure and function of neural microcircuits, particularly in the neocortex. This group is headed by Prof. Henry Markram and includes research scientist Dr. Rodrigo de Campos Perin, who is working with a combination of fluorescence microscopy and patch clamping for intracellular electrophysiological recordings.