-
Super-Resolution Single Molecule Localization
The Lew lab is creating technology to image multidimensional trajectories of individual molecules in time and space, with one focus on understanding the structural dynamics of amyloid aggregation in diseases like Alzheimer’s.In collaboration with Jan Bieschke, UCL, the lab has developed a single-molecule localization microscopy (SMLM) technique called TAB, transient amyloid binding, to image the structure of amyloid protein aggregates over periods of hours to days.
-
diSPIM Light-Sheet
Prof. Matthias Weiss and PhD student Ivana Jeremic research challenging problems at the interface of physics and biology, focusing on understanding self-organization processes in living organisms.
-
Dual-Color Voltage Imaging
Dr. Davide Raccuglia and his team use the model organism Drosophila melanogaster (colloquially known as fruit fly) to study how the brain regulates sleep. Dr. Raccuglia told us more about his research, “What I’m particularly interested in is the functional neural architecture of sensory gates for sleep regulation.
-
Structured Illumination Microscopy (SIM)
Dr. Guy Hagen, Research Associate from the University of Colorado, Colorado Springs creates high performance image reconstruction methods and open-source software to process super-resolution microscopy data. In 2014 Dr. Hagen released ThunderSTORM, an ImageJ plug-in for automated processing of photo-activated localization microscopy (PALM) and stochastic optical reconstruction microscopy (STORM) data.1
-
Super-Resolution Microscopy at University of California, Berkeley
The Ke Xu Group at the University of California Berkeley, College of Chemistry is an interdisciplinary lab that combines biophysics, physical chemistry and cell biology. Their goal is to understand how orders emerge in biological systems at the nano-meter scale from the interaction between biomolecules.
-
TIRF Microscopy at the University of Pittsburgh
Gerry Hammond studies membrane trafficking and intracellular signaling and regulation in the Center for Biologic Imaging at University of Pittsburgh. Working with Simon Watkins, Director of the Center, they use gene editing technology to fuse GFP to endogenous alleles.
-
Single Molecule Imaging at University of Zürich
The electrostatic properties of macromolecules—specifically, their electrical charge and interior dielectric characteristics— are a vital component of their function as they contribute to the physical basis of mechanisms that range from molecular recognition, signalling and enzymatic catalysis to protein folding and aggregation, and are of fundamental relevance in experiment and theory.
-
High-Speed Starscape Astronomy
Prof. Richard Gomer at Texas A&M University is involved with astronomy research beyond the reaches of the solar system. Prof. Gomer told us more about his research, “A simple question in astronomy is whether or not there is material associated with the solar system well out past the orbit of Pluto.
-
TIRF Microscopy, Physics of Cellular Interactions Group
The group of Dr. Ganzinger is interested in the basic physical principles of immunological signaling. The group uses synthetic biology to reconstitute signaling pathways, and single molecule imaging to enable them to understand how receptors and ligands work together to transmit signals through the cell.
-
Single Molecule Imaging
Redmar Vlieg’s research, within the group of John van Noort, primarily involves the use of two-photon microscopy to investigate biological processes in zebrafish embryos and in vitro measurements on gold nanorods (GNRs).
-
High Content Imaging
Dr. Chris Toepfer is a principal investigator interested in understanding how cardiac physiology changes in inherited cardiovascular conditions. The lab uses fluorescence microscopy and calcium imaging to observe how cellular contractility is affected across different heart conditions, such as those seen in professional sports.
-
Live Cell Imaging at Bastin Lab
The lab of Dr. Philippe Bastin at Institut Pasteur is primarily interested in improving understanding of the trypanosome parasites, which are significant in human health due to their role in sleeping sickness. The trypanosomes also offer a useful experimental model to increase understanding of cilia and flagella function.