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Light-Sheet Microscopy at Max Planck Institute for the Science of Light (MPL), Germany
Dr. Rui Ma is working on the development of optical microscopy systems at MPL, and is currently involved with building a light sheet microscope in order to image zebrafish, a biological model system used by colleagues at MPL to study spinal cord injury.
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Functional Light Sheet Calcium Imaging
The Bianco Lab at UCL aims to understand the logic of brain circuits that control behavior. Using two‑photon and light-sheet microscopy with small, optically transparent larval zebrafish expressing genetically encoded calcium indicators (GECIs), researchers such as Dr. Asaph Zylbertal record activity at single-cell resolution throughout the brain.
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Simultaneous Multiplane Phase Imaging
The lab of Dr. Kristin Grussmayer develops light microscopy and analysis tools for life sciences and biophysics research, in particular addressing questions in molecular and cell biology.
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DNA PAINT Super Resolution
Dr. John Danial works as part of the Klenerman Lab to develop biophysical approaches to complex neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. In these diseases certain proteins can accumulate in the brain and form aggregates, these aggregates can be investigated using extremely sensitive super-resolution microscopy, to uncover the mechanisms of brain diseases.
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Live-Cell Single-Molecule Fluorescence
Prof. Christof Gebhardt, along with PhD student Devin Assenheimer and the team from Ulm University told us about their research. “We perform single-molecule fluorescence microscopy both in vitro and in vivo within cells, with the aim to also image small organisms.
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Organoid Light Sheet Imaging
Dr. Franziska Decker aims to follow the differentiation of tissues and the development of organoids in 3D using a custom-built light sheet microscope. This work is mainly done with kidney organoids and gastruloids.
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iSIM Live Cell Imaging
The Dickinson lab aims to understand the generation of polarity in cells, namely when two ends of a living cell become molecularly distinct from each other. Polarity is vital for the proper function of cells and can become disrupted in diseases such as cancer.
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Live Cell Microfluidic Platform
Mekonos Inc. is a start-up company developing a biomedical microelectromechanical system (bio-MEMS) platform based on semiconductor and microfluidic technologies, to enable single-cell transfection with high viability and a scalable workflow.
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Delayed Fluorescence Imaging
The Anthony Hall group is a world-leading lab with a focus on understanding wheat genomics. Their work seeks to bridge the gap between traditionally used model plant organisms and crop species with real-world applications.
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FRET Voltage Imaging
Prof. Jiulin Du’s group is engaged in understanding the mechanisms of how multiple sources of sensory information are integrated in our central nervous system in order to execute behaviors. They investigate neuronal activity through in vivo electrophysiological recording and optical imaging on the model organism zebrafish.
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High-Speed Voltage Imaging
The lab of Prof. Xue Han uses optical methods to probe neural circuits in awake animals. With a background in optogenetics, Prof. Han has developed many key molecular tools for optogenetics, including SomArchon, an archaerhodopsin-based voltage sensor.
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High Content Multiplex Fluorescence at Institute of Science and Technology Austria
The lab of Prof. Johann Danzl focuses on research and development of cutting-edge technology to study biological phenomena at time and length scales that would be inaccessible with existing approaches. Conventional light microscopes are limited by diffraction and achieve a resolution of approximately half the wavelength of light used for imaging.