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  • In Vivo Fluorescence Imaging in the NIR-II Spectral Region for Early Cancer Detection

    UV, VIS, and NIR-I detection methods have been used in various scientific and medical applications for decades. Each of these approaches, however, has its limitations.

  • Ultrafast ICCD Cameras Enable Three-Pulse Ballistic Imaging Technique

    Although the use of sprays for industrial processes such as material deposition, cutting, and mixing is widespread, the design and testing of most spray devices is still predominantly phenomenological, owing not only to limitations in computing power but to gaps in the fundamental understanding of the multiphase fluid phenomena that drive spray breakup and morphology 1,2.

  • NIR-II Probes for In vivo Imaging

    Optical fluorescence imaging is one of the most common techniques for imaging in vivo, due to its high temporal and spatial resolution [1]. As it is a non-invasive, real-time technique it is an attractive imaging modality for medical applications such as cancer diagnostics, biosensing, and medical testing.

  • High-Harmonic Generation (HHG) and Highly-Sensitive Scientific Cameras for Soft X-ray Applications

    As is the case with many scientific and commercial technologies, the x-ray imaging and spectroscopy instruments utilized to perform leading-edge academic and industrial research are becoming smaller, more cost effective, and — in a sense — more personalized.

  • X-ray μCT Provides Nondestructive, High-Resolution 3D Imaging

    Since the early 1970s, x-ray computed tomography (CT) has been one of the most versatile, non-invasive investigative techniques in the medical field. It has also enabled nondestructive investigations in many other fields over the past few decades, including industry, archaeology, life science, geoscience, and crime investigations.

  • Dr. Florian Condamine

    Dr. Florian Condamine works at the Extreme Light Infrastructure (ELI) Beamlines, a European research institute offering highly intense laser systems and high energy radiation to enable research in the fields of physical, biomedicine, material science and more.Dr Condamine and his team have developed a high-repetition rate solid samples delivery system for PW-class laser-matter interaction. This instrumentation can measure 1000s of interactions within one experiment without having to replace the target, increasing the data quality and statistical reliability, while reducing overall experimental time.

  • Direct Detection of X-rays (30 eV to 20 keV) Using Detectors Based on CCD Technology

    CCDs have become increasingly specialized to meet the changing requirements of both commercial and scientific markets. In the scientific market, CCDs have been improved and optimized in a variety of ways to provide high performance across a broad set of applications

  • High Dynamic Range, Hyperspectral and Multidimensional CARS Measurements of Combustion Gases

    Dr. Brian Petersons lab at University of Edinburgh investigates the fluid dynamics and heat transfer in combustion gases with laser based analysis methods and spectroscopy. Combustion chamber like a car engine have steep temperature gradients between the cold walls at 300-400k and burning gas at temperatures of several thousand Kelvin.

  • Ultra-High-Sensitivity emICCD Cameras Enable Diamond Quantum Dynamics Research

    Interest in the various crystal defects found within diamonds is growing quickly amongst physicists and biologists worldwide. This increasing attention is attributable in no small part to the ability of such defects, when embedded in nanocrystals, to function as single-photon sources or as highly photostable, low-cytotoxicity fluorescent biomarkers.1

  • Ultra-Multiplex CARS Spectroscopic Imaging of Living Cells

    Popular molecular imaging techniques are only able to reveal the distribution or behavior of specific molecules within the human body that have been labeled with pigments or fluorescent proteins. Raman spectroscopy, however, allows researchers to identify the components of unlabeled molecules via spectral analysis.

  • Spinning disc confocal microscopy in the NIR-II window

    Near-infrared (NIR) fluorescent is a technique used widely within biological and medical research due to ability for NIR light to penetrate deeply in biological specimens, the high spatiotemporal resolution that it offers, and the capability to image quickly (Fan 2019).

  • Scientific InGaAs Cameras For NIR-II Imaging for Drug Discovery/Small-Animal Research

    For decades, x-ray and UV-vis-NIR detection methods have been used in various scientific, military, and medical applications. Although generally employed to good success, these systems nonetheless have some limitations when utilized for such types of work.