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Spinning Disk Confocal at University of Manchester
The research being performed at the University of Manchester has a real-world impact beyond the lab. The team is at the forefront of the search for solutions to some of the most pressing issues in biology, medicine and health
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Spinning Disk Confocal at University of Edinburgh
The group of Professor Seth Grant are interested in whole-brain synaptome mapping with an aim to understand more about how synaptic proteins are distributed and the role the molecular heterogeneity of synapses plays in health and brain disease.There are more than 1000 genes encoding proteins in the excitatory postsynaptic density alone, and the group aims to catalog as many synaptic proteins and protein subtypes in both excitatory and inhibitory pre and post-synaptic densities.
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STORM & Photonics
The Photonics Group in the Physics Department at Imperial College London develops instrumentation for multidimensional fluorescence imaging – spanning a wide range of applications, from super-resolved microscopy through automated fluorescence lifetime imaging for high content assays to endoscopy and optical tomography.The availability of Scientific CMOS cameras has been transformative for their research because the technology provides unprecedented imaging performance with high resolution and high frame rates. The team particularly uses Scientific CMOS cameras for localization and light sheet microscopy.
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Live Cardiac 3D Spinning-Disk
Prof. Francesco Pasqualini is a Harvard-trained bioengineer leading the synthetic physiology laboratory at the University of Pavia, currently researching cardiac development using engineered cell culture platforms.
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Calcium Imaging at Karolinska Institutet, Sweden
Dr. Wiktor Phillips is primarily interested in observing the pattern generation of respiratory rhythms in mammals through the study of the pre-Bötzinger complex in the medulla of the brainstem, and whether these patterns are affected by birth and related to respiratory dysfunction in newborns.
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Super-Resolution Single Molecule Localization
The Lew lab is creating technology to image multidimensional trajectories of individual molecules in time and space, with one focus on understanding the structural dynamics of amyloid aggregation in diseases like Alzheimer’s.In collaboration with Jan Bieschke, UCL, the lab has developed a single-molecule localization microscopy (SMLM) technique called TAB, transient amyloid binding, to image the structure of amyloid protein aggregates over periods of hours to days.
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diSPIM Light-Sheet
Prof. Matthias Weiss and PhD student Ivana Jeremic research challenging problems at the interface of physics and biology, focusing on understanding self-organization processes in living organisms.
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Dual-Color Voltage Imaging
Dr. Davide Raccuglia and his team use the model organism Drosophila melanogaster (colloquially known as fruit fly) to study how the brain regulates sleep. Dr. Raccuglia told us more about his research, “What I’m particularly interested in is the functional neural architecture of sensory gates for sleep regulation.
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Structured Illumination Microscopy (SIM)
Dr. Guy Hagen, Research Associate from the University of Colorado, Colorado Springs creates high performance image reconstruction methods and open-source software to process super-resolution microscopy data. In 2014 Dr. Hagen released ThunderSTORM, an ImageJ plug-in for automated processing of photo-activated localization microscopy (PALM) and stochastic optical reconstruction microscopy (STORM) data.1
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Super-Resolution Microscopy at University of California, Berkeley
The Ke Xu Group at the University of California Berkeley, College of Chemistry is an interdisciplinary lab that combines biophysics, physical chemistry and cell biology. Their goal is to understand how orders emerge in biological systems at the nano-meter scale from the interaction between biomolecules.
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3rd Party Software: Python
Python is a general-purpose, high-level, interpreted programming language that allows for quick and effective system integration through the use of dynamic typing and reference counting.
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3rd Party Software: EPICS for PICAM
EPICS is an Open Source project that is freely available and developed collaboratively from multiple scientific facilities. The powerful and reliable software makes it the preferred choice for applications using large scale, complex distributed control systems.